Establishing and Validating a New Therpauetic Target for Colon and Stomach Cancer

Laminin 521 enhances self-renewal via STAT3 activation and promotes tumor progression in colorectal cancer

Y Qin, C Shembrey, J Smith, S Paquet-Fifield, C Behrenbruch, LM Beyit, BNJ Thomson, AG Heriot, Y Cao, F Hollande

2020-04-28

Remodeling of basement membrane proteins contributes to tumor progression towards the metastatic stage. One of these proteins, lam..

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

MF Eissmann, C Dijkstra, A Jarnicki, T Phesse, J Brunnberg, AR Poh, N Etemadi, E Tsantikos, S Thiem, ND Huntington, ML Hibbs, A Boussioutas, MA Grimbaldeston, M Buchert, RJJ O’Donoghue, F Masson, M Ernst

2019-12-01

The contribution of mast cells in the microenvironment of solid malignancies remains controversial. Here we functionally assess th..

Impact of tumor and immunological heterogeneity on the anti-cancer immune response

C Shembrey, ND Huntington, F Hollande

2019-09-01

Metastatic tumors are the primary cause of cancer-related mortality. In recent years, interest in the immunologic control of malig..

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.

Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar-Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael Dw Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand

2019-01-01

Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in soli..

Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells

Sophie Paquet-Fifield, Shir Lin Koh, Lesley Cheng, Laura M Beyit, Carolyn Shembrey, Christina Molck, Corina Behrenbruch, Marina Papin, Meritxell Gironella, Sophie Guelfi, Ramona Nasr, Fanny Grillet, Michel Prudhomme, Jean-Francois Bourgaux, Antoni Castells, Jean-Marc Pascussi, Alexander G Heriot, Alain Puisieux, Melissa J Davis, Julie Pannequin

2018-06-01

Posttreatment recurrence of colorectal cancer, the third most lethal cancer worldwide, is often driven by a subpopulation of cance..

A spatio-temporal model and inference tools for longitudinal count data on multicolor cell growth

P Qiao, C Mølck, D Ferrari, F Hollande

2018-01-01

Multicolor cell spatio-temporal image data have become important to investigate organ development and regeneration, malignant grow..

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture

F Grillet, E Bayet, O Villeronce, L Zappia, EL Lagerqvist, S Lunke, E Charafe-Jauffret, K Pham, C Molck, N Rolland, JF Bourgaux, M Prudhomme, C Philippe, S Bravo, JC Boyer, L Canterel-Thouennon, GR Taylor, A Hsu, JM Pascussi, F Hollande

2017-10-01

Objective Although counting of circulating tumour cells (CTC) has attracted a broad interest as potential markers of tumour progre..

Laminins and cancer stem cells: Partners in crime?

Y Qin, S Rodin, OE Simonson, F Hollande

2017-08-01

As one of the predominant protein families within the extracellular matrix both structurally and functionally, laminins have been ..

The JAK/STAT3 axis: A comprehensive drug target for solid malignancies

J Huynh, N Etemadi, F Hollande, M Ernst, M Buchert

2017-08-01

Intercellular communication between tumor cells, immune cells and the stroma characterises the tumor microenvironment, which is in..

The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism

C Mølck, J Ryall, LM Failla, JL Coates, JM Pascussi, JK Heath, G Stewart, F Hollande

2016-12-01

Purpose Adenosine is a multifaceted regulator of tumor progression. It modulates immune cell activity as well as acting directly o..

Mouse models for gastric cancer: Matching models to biological questions

AR Poh, RJJ O'Donoghue, M Ernst, TL Putoczki

2016-07-01

Gastric cancer is the third leading cause of cancer-related mortality worldwide. This is in part due to the asymptomatic nature of..

Autocrine secretion of progastrin promotes the survival and self-renewal of colon cancer stem-like cells

J Giraud, LM Failla, JM Pascussi, EL Lagerqvist, J Ollier, P Finetti, F Bertucci, C Ya, I Gasmi, JF Bourgaux, M Prudhomme, T Mazard, I Ait-Arsa, L Houhou, D Birnbaum, A Pélegrin, C Vincent, JG Ryall, D Joubert, J Pannequin

2016-06-15

Subpopulations of cancer stem-like cells (CSC) are thought to drive tumor progression and posttreatment recurrence in multiple sol..

Pregnane X-receptor promotes stem cell-mediated colon cancer relapse

C Planque, F Rajabi, F Grillet, P Finetti, F Bertucci, M Gironella, JJ Lozano, B Beucher, J Giraud, V Garambois, C Vincent, D Brown, L Caillo, J Kantar, A Pelegrin, M Prudhomme, J Ripoche, JF Bourgaux, C Ginestier, A Castells

2016-01-01

Colorectal cancer lethality usually results from post-treatment relapse in the majority of stage II-IV patients, due to the enhanc..

Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer

CN Johnstone, A Chand, TL Putoczki, M Ernst

2015-10-01

Interleukin (IL)-11 is a member of the IL-6 family of cytokines that is defined by the shared use of the GP130 signal transducing ..

Culture of circulating tumor cells in colorectal cancer : a new tool for personalised medicine?

F Grillet, L Lagervist, E Bayet, S Lunke, N Rolland, J-F Bourgaux, M Prudhomme, G Taylor, J-M Pascussi, F Hollande, J Pannequin

2015-06-01

STAT3-activating cytokines: A therapeutic opportunity for inflammatory bowel disease?

PM Nguyen, TL Putoczki, M Ernst

2015-05-01

The gastrointestinal tract is lined by a single layer of epithelial cells that secrete mucus toward the lumen, which collectively ..

IL-11 signaling as a therapeutic target for cancer

TL Putoczki, M Ernst

2015-04-01

IL-11 is a member of the IL-6 family of cytokines. While it was discovered over 20 years ago, we have very little understanding of..

Role of PXR nuclear receptors in the chemoresistance potential of cancerous stem cells in colon cancer

C Planque, L Caillo, J Pannequin, D Joubert, F Hollande, J-M Pascussi

2011-10-01